Last update
3/16/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 3 capsules
Amount Per Serving
%DV
Organic Milk Thistle seed (Silybum marianum)
1260 mg
†
Organic Milk Thistle seed powdered extract (Silybum marianum) standardized to 80% silymarin
240 mg
†
Top Medical Research Studies
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
Most Useful Reviews
9
Normal blood test
1 people found this helpful
I purchased this to enhance my liver enzymes, and it certainly works. My latest blood test came back normal. Additionally, iHerb ships very quickly to the U.K.
Read More
7.5
Feeling better
This is excellent for liver support. My husband takes it to aid his liver in recovering from excessive alcohol intake. He feels better, though we haven’t conducted another blood test yet.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normal blood test
1 people found this helpful
I purchased this to enhance my liver enzymes, and it certainly works. My latest blood test came back normal. Additionally, iHerb ships very quickly to the U.K.
Read More
7.5
Feeling better
This is excellent for liver support. My husband takes it to aid his liver in recovering from excessive alcohol intake. He feels better, though we haven’t conducted another blood test yet.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Speciale A, Muscarà C, Molonia MS, Cimino F, Saija A, et al. Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects. Phytother Res. 2021;35:4616. 10.1002/ptr.7107
- Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. 10.1186/s12906-017-1897-7
Data last updated:
